I am a mainline organically based clinician who has been looking at the field of Chronic Fatigue Syndrome now for  20 years. I spent 12 years as Medical Adviser to the Myalgic Encephalomyelitis Association based in Stanford-le-Hope, and wrote and published, after peer review, some ten papers based on the concept that this illness was caused, sustained and maintained by a virus of one kind or another.

In 1990, it became quite clear that this illness was simply triggered by a virus and in many cases I was convinced that viruses were not involved. The virus, therefore, if found in the blood became irrelevant. In 1992, it became clear that the fatigue syndrome was purely centrally based and that problem was simply that of disturbed brain function. With further work it became clear that every neurone within the central nervous system is effected and neural networks suggest that a diminished brain function would be associated with diminished neurotransmitter regulation. Thus a treatment became apparent and that it would be a neurotransmitter regulator; in other words, the use of antidepressants became axiomatic.

Fortunately seventy percent of neural transmission is made by five neurotransmitters namely 5Hydroxitriptyline, Nor-adrenaline, Adrenaline, Gamma Amino Butyric Acids and Endorphins. There are of course thousands of other neurotransmitters present in very much reduced amounts. By using a tailor made mixture of Tricyclic Antidepressants at night and stimulating 5HT re-uptake inhibitors in the morning the treatment approach began in 1994. Since then, having had a poor treatment outcome previously the effect upon this illness has been dramatic. All of this, of course at the moment, is anecdotal and can only be proven by peer review published papers which are currently being written.  My paper, written with others, relating to the treatment of children is due to be published in Archives of Diseases of Childhood in October 2003 and will demonstrate  that this illness is now effectively curable.

I would like to invite you to participate in examining my concept and treatment programme which follows on my Web Site.   This is intended to be an information only service - I am afraid that I cannot enter into personal responses.

I hope that you find this interesting, sensible and progressive.

With best wishes

DR DAVID GEOFFREY SMITH M.B. Ch.B. B.Sc.

September 2003